Total pancreatectomy removes the entire pancreas, often for extensive pancreatic cancer, chronic pancreatitis, or multiple tumors. Symptoms include abdominal pain, weight loss, jaundice, or digestive issues. The procedure, typically open, may also involve removing the spleen, duodenum, and bile duct. It results in permanent diabetes and digestive enzyme deficiency, requiring lifelong insulin and enzyme replacement. Risks include infection, bleeding, or nutritional deficiencies. Recovery involves a prolonged hospital stay and months of adaptation, with strict dietary and medication regimens. Follow-ups monitor blood sugar, nutrition, and cancer recurrence. The surgery is high-risk but necessary for widespread disease, improving survival in select cases. Patients need extensive support to manage diabetes and digestion, with long-term care focused on maintaining health and quality of life post-surgery.